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KMID : 0923620140140050000
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Immune Network
2014 Volume.14 No. 5 p.0 ~ p.0
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Regulatory T Cells in B Cell Follicles
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Chang Jae-Hoon
Chung Yeon-Seok
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Abstract
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Understanding germinal center reactions is crucial not only for the design of effective vaccines against infectious agents and malignant cells but also for the development of ther-apeutic intervention for the treatment of antibody-mediated immune disorders. Recent advances in this field have re-vealed specialized subsets of T cells necessary for the con-trol of B cell responses in the follicle. These cells include fol-licular regulatory T cells and Qa-1-restricted cluster of differ-entiation (CD)8＋ regulatory T cells. In this review, we dis-cuss the current knowledge related to the role of regulatory T cells in the B cell follicle.
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KEYWORD
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Germinal center, B cell, Follicular helper T cell, Foxp3＋ regulatory T cell, Qa-1 restricted CD8＋ regulatory T cell, Autoantibody
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